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LOIS-3D

Laser Optoacoustic Imaging System provides quantitative optoacoustic tomography, qOAT, of the live mouse body and brain

Tomowave's LOIS-3D is a cutting-edge imaging system that utilizes laser optoacoustic and ultrasonic technology to generate high-resolution, three-dimensional images of biological tissues. Designed for both preclinical research and translational studies, it provides detailed insights into tissue composition, function, and pathology with exceptional depth and contrast.

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TomoWave develops proprietary optoacoustic tomography and laser ultrasound systems for combined functional/molecular and anatomical imaging with applications in detection of cancer and image-guided interventions

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LOIS-3D

Laser Optoacoustic Imaging System provides quantitative optoacoustic tomography, qOAT, of the live mouse body and brain

The LOIS-3D (Laser Optoacoustic Imaging System) by TomoWave Laboratories is a state-of-the-art imaging platform designed for high-resolution, non-invasive, three-dimensional visualization of small animals, particularly mice, in preclinical research. By integrating light and sound, LOIS-3D delivers quantitative optoacoustic tomography (qOAT), providing detailed anatomical, molecular, and functional insights into live biological tissues.

Full-View 3D Imaging

Broad Spectral Range

High Sensitivity

Rapid Temporal Resolution

Multimodal Imaging Capabilities

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Frequently Asked
Questions

The LOIS-3D (Laser Optoacoustic Imaging System) by TomoWave Laboratories is a cutting-edge tool designed to provide high-resolution, non-invasive, 3D imaging of small animals for preclinical research. Whether you're a researcher exploring its capabilities for the first time or an experienced user seeking technical specifics, this FAQ addresses common questions about LOIS-3D’s features, applications, and how it supports a wide range of biomedical investigations.

What is the LOIS-3D system, and how does it function?

The LOIS-3D (Laser Optoacoustic Imaging System) is an advanced imaging platform designed for high-resolution, non-invasive, three-dimensional visualization of small animals, particularly mice, in preclinical research. It employs optoacoustic tomography (OAT), a technique that combines the high contrast of optical imaging with the spatial resolution of ultrasound. By delivering nanosecond laser pulses into biological tissues, the system induces thermoacoustic waves, which are then detected by ultrasonic transducers to reconstruct detailed 3D images of internal structures.

What are the key features and capabilities of LOIS-3D?

    • Full-View 3D Imaging: Utilizes a 360° rotational scanning mechanism with a concave arc-shaped transducer array to reconstruct volumetric images with isotropic spatial resolution of approximately 150 microns. Amerigo Scientific

    • Broad Spectral Range: Employs tunable laser wavelengths from 660 nm to 2300 nm, enabling deep tissue imaging and the detection of various chromophores and contrast agents.

    • High Sensitivity: Capable of detecting low concentrations (~1 picomolar) of absorbing nanoparticles, such as gold and silver, facilitating studies in nanomedicine and targeted drug delivery.

    • Rapid Temporal Resolution: Advanced versions offer temporal resolution of 5 seconds per 3D volumetric image, allowing dynamic monitoring of physiological processes.

    • Multimodal Imaging Capabilities:

      • Anatomical Imaging: Visualizes internal structures like organs, vasculature, spine, bones, and skin with high contrast and resolution.

      • Functional Imaging: Maps oxygen saturation and total hemoglobin content using multi-wavelength spectroscopy, critical for assessing tissue oxygenation and blood volume.

      • Molecular Imaging: Tracks the biodistribution of optical contrast agents over time, aiding in pharmacokinetic studies and drug development.

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What are the primary applications of LOIS-3D in biomedical research?

LOIS-3D is instrumental in various research domains, including:

  • Cancer Biology and Oncology: Enables visualization of tumor vasculature and monitoring of tumor progression.

  • Drug Development: Assists in evaluating the efficacy and distribution of therapeutic agents.

  • Bio-Nanotechnology: Facilitates studies on nanoparticle behavior and targeting within biological systems.

  • Developmental Biology: Supports research on embryonic development and organogenesis.

  • Neurophysiology: Allows for the examination of cerebral blood flow and brain function in small animal models.

How can researchers acquire or learn more about the LOIS-3D system?

Researchers interested in the LOIS-3D system can visit the official TomoWave Laboratories website at www.tomowave.com. For direct inquiries, they can contact TomoWave Laboratories via email at general@tomowave.com or by phone at +1-713-270-5393.

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Kim Tillinghast

CPFAâ„¢, Principal, Partner

Kim Tillinghast began her career in the banking industry in 1985. She graduated with a degree in Finance from West Texas State University in 1990 and has continued her education by earning her Series 24 General Securities Principal Exam and Certified Plan Fiduciary Advisor (CPFA™). Shortly thereafter she started her brokerage career at a traditional wirehouse in downtown Los Angeles, California in 1991. After relocating to Orange County, Kim became an independent financial advisor in May of 1993. She brings over 37 years in the banking and finance industry with experience ranging from designing, developing, employing and maintaining complex investment strategies, Pension Plans, Employee Stock Option Plans, Corporate Finance, Estate Planning and Transition. Outside of her career, she served as Co-Chair of the Dallas County Susan G. Komen Race for the Cure 2013 and 2014 and currently serves on the Board of the Tillinghast Society, Inc. With a deep love for animals, she continues to volunteer for multiple emergency animal response teams including Red Rover, HSUS, UAN, ASPCA and volunteers weekly at the Irving Animal Shelter. Kim also loves worldwide adventure travel and has many amazing experiences visiting almost half of the world’s countries and all seven continents, twice.

Karthik Muraliraj

CFP®, ChFC®, CLU®, RMA®, Partner

Karthik Muraliraj was raised in Fort Worth, Texas, and developed an interest in investing and economics at a young age. After graduating from the University of Texas at Austin with a Bachelor of Arts in Economics and a minor in Business, he started his career as a financial professional in 2008. Throughout his career, Karthik has continued to educate himself by gaining multiple designations. Since moving to Dallas, he has been an active member in the community—volunteering with organizations such as the network of Indian Professionals, Dallas Autumn Ball and Reading Partners. Karthik is an avid sports fan and enjoys supporting his alma mater as a proud member of the Texas Exes Dallas Chapter. In his free time, Karthik enjoys cooking, travel, fitness and spending time with this wife, son, dog, and cat.

Crystal Arredondo

MBA, CDFA®, CPFA™, Partner

Crystal Arredondo was born and raised in Germany. She moved to Texas following her parents’ decision to retire after serving an overseas career in the Armed Forces. Seeing firsthand the difficult transition to civilian life after retirement, Crystal obtained her MBA in Finance at the University of North Texas and began her career as a financial advisor. In 2009, she completed the Retirement Planning Specialist Program at the Wharton School of Business, University of Pennsylvania. In 2018, she earned her designation of Certified Divorce Financial Analyst® (CDFA®). In 2022, she earned the additional designation as a Certified Plan Fiduciary Advisor (CPFA™). As the daughter of an immigrant mother, she especially enjoys helping women and business owners make decisions that affect their financial independence. She served as the 2015-16 Chair for the National Association of Women Business Owners (NAWBO) and 2016-17 Chair for the NAWBO Institute of Entrepreneurial Development.

Philip Strunk

CFP®, CPA, Partner

Philip Strunk is a native of Houston, TX. Philip earned his Bachelor of Business Administration and Masters in Professional Accounting from the University of Texas at Austin’s McCombs School of Business. He earned his designation as Certified Public Accountant (CPA) in 2004 and CERTIFIED FINANCIAL PLANNER (TM) certification in 2010. Having started his career with Deloitte & Touche, LLP in 2005, Philip spent a year and a half in Deloitte’s Audit and Assurance Services group and provided a variety of financial services for a number of Fortune 500 companies. He decided in late 2006 that his talent and passion for investments were best suited for working with smaller groups and individuals. After obtaining the required securities registrations and insurance licenses, Philip became a financial advisor. The impact was plainly visible and more fulfilling. Philip serves as the Investment Director for MPACT.

John C. Farris

CAP®, CFS®, Partner

John C. Farris is a founding partner and has more than forty years in both public and private business serving in a variety of management and leadership capacities. John completed the Retirement Planning Specialist Program at the Wharton School of Business at the University of Pennsylvania earning the Retirement Planning Specialist designation. John and his family have a history of philanthropic giving through numerous non-profit organizations. John recently completed his designation as a Chartered Advisor in Philanthropy® (CAP®). He is also a member of The International Association of Advisors in Philanthropy. His primary goal is to help people give intelligently with love and thereby experience the true joy of helping others. John lives in Park Cities and has served on the Public Works Advisory Council, as finance director of the BSA West Park District, the BSA Troop 82 Executive Board, and as a BSA Assistant Scoutmaster for Troop 82, Dallas, Texas.